Towards Quantitative Renal MR Blood Oximetry by Combined Monitoring of T2*, T2 and Blood Volume Fraction Synopsis Acute kidney injuries are often characterized by tissue oxygen hypoxia. T2*-mapping permits probing renal oxygenation but provides a surrogate rather than a quantitative measure of oxygen saturation (SO2). The link between pO2 and T2* is influenced by changes in blood volume fraction (BVf). Monitoring BVf in combination with recently developed quantitative BOLD approaches could permit unambiguous interpretation of renal T2*. To test the feasibility of this new approach we monitored renal T2*/T2 during baseline and short periods of venous occlusion. This was performed in the same animal under naïve conditions and again with USPIO to permit estimation of BVf and SO2. Status: confirmed